The present invention provides a therapeutic and/or prophylactic pharmaceutical composition for bone metabolism disorder, the target of which is the protein encoded by a gene expressed in osteoclast strongly.Provided is a pharmaceutical composition comprising an antibody that is specific to recognize human Siglec-15 and has an activity for inhibiting the formation of osteoclasts and the like.本發明提供骨代謝異常之治療及/或預防用醫藥組成物,其以於破骨細胞中強烈表現的基因所編碼的蛋白質為標的。提供包含專一性辨識人類Siglec-15且具有抑制破骨細胞之形成的活性之抗體的醫藥組成物等。
