Liang, Hong,Abdiche, Yasmina Noubia,Chaparro Riggers, Javier Fernando,Gomes, Bruce Charles,Hawkins, Julie Jia Li,Pons, Jaume,Qiu, Xiayang,Strop, Pavel,Wang, Yuli
申请号：
AU2013200743
公开号：
AU2013200743A1
申请日:
2013.02.12
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2013200743A120130307.pdf#####Abstract The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigenbinding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholes-terolemia.
