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PCSK9 antagonists
专利权人:
Pfizer Inc.
发明人:
Liang, Hong,Abdiche, Yasmina Noubia,Chaparro Riggers, Javier Fernando,Gomes, Bruce Charles,Hawkins, Julie Jia Li,Pons, Jaume,Qiu, Xiayang,Strop, Pavel,Wang, Yuli
申请号:
AU2013200743
公开号:
AU2013200743A1
申请日:
2013.02.12
申请国别(地区):
AU
年份:
2013
代理人:
摘要:
#$%^&*AU2013200743A120130307.pdf#####Abstract The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigenbinding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholes-terolemia.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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