Research Institute at Nationwide Children’s Hospital
发明人:
LEE, Dean Anthony,FOLTZ-STRINGFELLOW, Jennifer Ann,EDWARDS-MOSEMAN, Jena
申请号：
SG11202007288V
公开号：
SG11202007288VA
申请日:
2019.01.29
申请国别(地区):
SG
年份:
2020
代理人:
摘要：
An NK cell with low SMAD3 expression and altered gene expression profile resulting in high cytokine expression and TGF-β superfamily resistance is described, refered to herein as TGF-β superfamily-imprinted Natural Killer Cells (TGFβi NK cells). A method of treating cancer or infection in a subject in need thereof is described. The method includes administering a therapeutically effective number of TGFβi NK cells to the subject. A method of producing TGFβi NK cells is described by in vitro activation of natural killer cells in the presence of a TGF-β superfamily cytokine.
