PROBLEM TO BE SOLVED: To provide an antioxidant, ceramide production promoter, cell growth promoter, wrinkle preventing or improving agent, 5&alpha；-reductase inhibitor, hair tonic, and preventive or therapeutic agent for acne and prostatic disease which contain Lonicera gracilipes extract.SOLUTION: Lonicera gracilipes extract of the invention has an excellent anti-oxidant action, ceramide production promoting action, cell growth promoting action, wrinkle preventing or improving effect, and 5&alpha；-reductase inhibitory action, being also excellent in stability. A topical preparation for skin containing Lonicera gracilipes extract is also effective in the prevention or therapy for various skin aging and male pattern hair loss, acne, prostatic disease, or the like.
