Disclosed is a degassing device (100) for removing gas bubbles from a liquid drug stream, the degassing device including:a) an inlet chamber (102), with an inlet opening (104), an outlet chamber (106) with an outlet opening (108), and a degassing opening (114), andb) a hydrophilic membrane (110) and a hydrophobic membrane (112),wherein• the hydrophilic membrane (110) fluidically couples the inlet chamber (102) with the outlet chamber (106), thus enabling a transfer of liquid from the inlet chamber (102) to the outlet chamber (106) through the hydrophilic membrane (110),• the hydrophobic membrane (112) fluidically couples the inlet chamber (102) wit the degassing opening (114), thus enabling a transfer of gas from the inlet chamber (102) to the degassing opening (114) through the hydrophobic membrane 112, and• the hydrophilic membrane (110) and the hydrophobic membrane (112) are joint along a joint (116) to establish a joined membrane (110 112) such that a contact line of a liquid-gas phase separation on the joined membrane (110, 112) does not coincide with the joint (116) independent of an orientation of the degassing device (100) with respect to gravity.Disclosed is further an ambulatory infusion system comprising such a degassing device.
