ABSTRACT Computer-aided design and manufacturing has been successfully used in prosthetic application since 1980s. The lower limb amputation is one of the major drawback in the patients day-to-day activities, who have lost their lower limbs. Currently thermoplastic materials such as polypropylene and acrylic as well as thermoset resins such as polyester, epoxy and polyurethane were used for the manufacturing of socket. In general, an uneven shear stress and .interface pressure distribution between the socket-stump interface develop during human walk plays a major role in doing the daily activities with prosthetic components, However the prediction of stress distribution was a challenge due to the different socket dimension for each individual. Hence, an attempt was made in this direction to predict the stress distribution as well as to find out the suitable material used for the trans-femoral socket. The Finite element analysis (FEA) was used to find the stress distribution with thickness of the socket. The stress distribution for the above mentioned thickness will be analyzed for posterior, anterior, medial and lateral direction of the stump. The socket thickness will be analysis based on the stress distribution and it may be expected that the material for the development of the trans-femoral socket will be suggested in detail.