A remote management, control and alert system for a medical air alternation mattress provided in the present disclosure comprises an integration and connection between internal and external devices/units. An internal pressure control device connected with at least one air inflation/deflation unit which connects with a plurality of air cushion units in an air mattress for regulated pressure of the air cushion units in the air mattress through the air inflation/deflation unit in a controlled manner; furthermore, the pressure control device is further connected with a manipulation device to operate or analyze the data processing device through the manipulation device, for controlled regulation of pressures in all parts of the air mattress. These aforementioned internal devices/units are then in turn connected to and integrated with an external managing device allowing the user to control, monitor and receive alert notifications for the entire integrated system or systems to which it is connected.