Oxo Compound 8 - 9 - [3 - (1h benzimidazole - 2 - iloxi) phenyl] - 4,5,6,7,8,9 hexahidro - 2H - pyrrolo [3,4-b] quinoline - 3 - carboxylate Ethyl, its Salts and preparation methods.

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专利权人:

SANOFI

发明人:

PASCAL BILLOT,CARRY JEAN -CHRISTOPHE,NATHALIE AROKIASSAMY,PATRICK CLAVIERES,CLERC FRANCOIS,CROCQ - STUERGA VERONIQUE,SYLVETTE LACHAUD,PHILIPPE LIENARD,MENEGOTTO JEROME,LAURENT SCHIO

申请号：

UY33738

公开号：

UY33738A

申请日:

2011.11.17

申请国别(地区):

UY

年份:

2012

代理人:

摘要：

The Invention relates more particularly to a New Salt, co Crystal and formulations of 8-oxog - 9 - [3 - (1h benzimidazole - 2 - iloxi) phenyl] - 4,5,6,7,8,9 hexahidro - 2H - pyrrolo [3,4-b] quinoline - 3 - carboxylate Ethyl formula (f) their preparations and their use in therapy, mainly as Selective inhibitors of Aurora Kinases a and B, and to their use as Anticancer.La invención se refiere más precisamente a una nueva sal, co-cristal y formulaciones de 8-oxo-9-[3-(1H-bencimidazol-2-iloxi)-fenil]-4,5,6,7,8,9-hexahidro-2H-pirrolo[3,4-b]quinolina-3-carboxilato de etilo de fórmula (F) a sus preparaciones y a su utilización en terapéutica, principalmente como inhibidores selectivos de las quinasas Aurora A y B, y para su utilización como anticancerosos.

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