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COMPOSITION OF DEXIBUPROFEN TRANSDERMAL HYDROGEL
专利权人:
SHASUN PHARMACEUTICALS LIMITED
发明人:
BERGMAN, JEFFREY STUART,DEVARAJAN, SAMPATHKUMAR,RAMALINGAM, SELVAKUMAR,PALANISAMY, ANANDSENTHIL VEL
申请号:
CA2784827
公开号:
CA2784827C
申请日:
2010.12.09
申请国别(地区):
CA
年份:
2018
代理人:
摘要:
Stable non-alcoholic transdermal hydrogel of dexibuprofen was prepared by using a simple manufacturing process, and the experimental trials showed that the pH modifying agent, antioxidant and water miscible solvent are the essential excipients to obtain stable non-alcoholic transdermal hydrogel of dexibuprofen. The dexibuprofen hydrogel prepared using carbopol as a gelling polymer produced an opaque gel, whereas hydrogel prepared using hyroxypropyl methylcellulose (HPMC) as a gelling polymer produced a transparent gel. There was no significant changes observed with respect to physical description, pH, assay and particularly to the related substance values when the hydrogels were subjected to the stability study at accelerated condition (40°C / 75% RH) for 3 months in laminated tubes.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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