GOTTSCHALK, STEPHEN M. G.,SHAFFER, DONALD R.,SPENCER, DAVID M.
申请号:
CA2816379
公开号:
CA2816379A1
申请日:
2011.10.27
申请国别(地区):
CA
年份:
2012
代理人:
摘要:
The present invention concerns methods and compositions related to T cells redirected against CD70 for the immunotherapy of CD70-positive malignancies. In aspects of the invention, T cells that are CD70-specific are employed. In particular aspects, there are T cells expressing a novel molecule that comprises the full-length CD70 receptor (CD27) fused to the zeta signaling domain of the T-cell receptor complex. Such T cells recognized CD70- positive tumor cells and have cytolytic activity against CD70-positive cancer cells.