Provided are a composition, an application thereof and a treatment method. The composition comprises a benzoheterocyclic compound represented by general formula (I), one or more from among a pharmaceutically acceptable salt thereof, a solvate, a crystal form, a cocrystal, a stereoisomer, an isotope compound, a metabolite and a prodrug, and an androgen receptor pathway modulator and/or a hormone drug. The composition and treatment method may effectively inhibit the growth of prostate cancer cells.
