DÉRIVÉS DE 1-(TRIAZIN-3-YL/PYRIDAZIN-3-YL)-PIPER(-AZINE)IDINE ET COMPOSITIONS LES CONTENANT POUR L'INHIBITION DE L'ACTIVITÉ DE SHP2

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专利权人:

Novartis AG

发明人:

申请号：

EP15703106.3

公开号：

EP3094629B1

申请日:

2015.01.16

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

The present invention relates to compounds of formula I: in which Y1, Y2, Y3, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b are defined in the Summary of the Invention； capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

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