A solid oral pharmaceutical composition comprises greater than 100 mg of imatinib, and one or more pharmaceutically acceptable excipients. A process for preparing a pharmaceutical composition comprising than greater than 100 mg of imatinib, and one or more pharmaceutically acceptable excipients comprises manufacturing a solid oral pharmaceutical composition by granulating imatimib with one or more pharmaceutically acceptable excipients. A solid oral pharmaceutical composition for use in medicine comprises greater than 100 mg of imatinib, and one or more pharmaceutically acceptable excipients.