Christopher L. Reyes,Kristen M. Smith,Peter Chu,Lioudmila A. Campbell,Eric Ailor
申请号：
US14741696
公开号：
US09631024B2
申请日:
2015.06.17
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Disclosed herein are anti-LGR4 antibodies for the treatment of cancer. Antibodies disclosed herein may bind LGR4 without disrupting LGR4-RSPO1 binding or signaling, and may disrupt LGR4 signaling through Wnt that is independent of RSPO1. Also disclosed are heavy and light chain polypeptide sequences for antibodies that bind LGR4, for example without disrupting LGR4-RSPO binding or signaling.
