A non-thermal plasma (NTP) system treats fluid flows (e.g., air) containing pollutants (e.g., VOCs particulate) using two or more stages, each operated to produce NTP with a respective frequency targeted toward one or more pollutants. NTP generation cell assemblies or dielectric barrier discharge devices are arranged in stages along a flow path. Parallel flow paths with multiple stages may be employed. NTP fields in successive stages operate at a different frequency, power density and/or waveforms, which are controlled to be a vibrational harmonic of a targeted compound. Power density can be adjusted to only create gaseous ionized species or to incinerate organic airborne, suspended particulate in situ. Automatic fault detection employs a split ground current so that an imbalance indicates a fault. A faulted component is automatically isolated. Automatic re-routing allows operation with only slightly degraded performance.
