Ring constrained analogs as arginase inhibitors

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专利权人:

Mars; Incorporated

发明人:

Michael Van Zandt,Gunnar Erik Jagdmann, Jr.

申请号：

US14391901

公开号：

US09200011B2

申请日:

2013.03.13

申请国别(地区):

US

年份:

2015

代理人:

摘要：

The inventive boronic acid analogs are potent inhibitors of Arginase I and II activity. These compounds are candidate therapeutics for treating a disease or disorder associated with an imbalance in the activity or concentration of cellular arginase I and arginase II enzymes. The invention also provides pharmaceutical compositions of the inventive compounds and methods for using the compositions for therapy.

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