1 kr) 71' O O N 00 O 1-1 N C (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 November 2018 (01.11.2018) WIPO I PCT mu °mons ono o Holonillioomunom oimIE (10) International Publication Number WO 2018/200645 Al (51) International Patent Classification: A61K 31/704 (2006.01) C07H 15/256 (2006.01) A61P 37/04 (2006.01) (21) International Application Number: PCT/US2018/029314 (22) International Filing Date: 25 April 2018 (25.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/489,556 25 April 2017 (25.04.2017) US (71) Applicant: ADJUVANCE TECHNOLOGIES, INC. [US/US]； 16 West 22nd Street, 6th Floor, New York, NY 10010 (US). (72) Inventors: LIVINGSTON, Philip； 156 East 79th Street, Apt. 6C, New York, NY 10075 (US). RAGUPATHI, Govind； 303 East 60th Street, #35G, New York, NY 10022 (US). GARDNER, Jeffrey； 116 W22nd St, Apt 1, New York, NY 10011 (US). MARTIN, J, Tyler； 5200 Quarry Ledge Road, Roca, NE 68430 (US). (74) Agent: STRAIN, Paul D.； Strain & Strain PLLC, 1455 Pennsylvania Ave, N.W., Suite 400, Washington, DC 20004 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM,
