Novel derivatives of enfumafungin are disclosed herein, along with their pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antifungal agents and/or inhibitors of (1,3)-β-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and/or preventing fungal infections and associated diseases and conditions.本文揭示英夫馬芬淨(enfumafungin)之新穎衍生物,以及其醫藥學上可接受之鹽、水合物及前藥。亦揭示包含此等化合物之組合物、製備此等化合物之方法及使用此等化合物作為抗真菌劑及/或(1,3)-β-D-葡聚糖合成酶抑制劑之方法。所揭示之化合物、其醫藥學上可接受之鹽、水合物及前藥以及包含此等化合物、鹽、水合物及前藥之組合物適用於治療及/或預防真菌感染以及相關疾病及病狀。
