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METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS AND/OR SUPPORTING CELLS
专利权人:
MASSACHUSETTS EYE AND EAR INFIRMARY
发明人:
Zheng-Yi Chen
申请号:
US14426520
公开号:
US20150209406A1
申请日:
2013.09.06
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Provided are methods and compositions for inducing cells of the inner ear (for example, cochlear and utricular hair cells) to reenter to cell cycle and to proliferate. More particularly, the invention relates to the use of agents that increase c-myc activity and/or Notch activity for inducing cell cycle reentry and proliferation of cochlear or utricular hair cells and/or cochlear or utricular supporting cells. The methods and compositions can be used to promote the proliferation of hair cells and/or supporting cells to treat a subject at risk of or affected with, hearing loss or a subject at risk of or affected with vestibular dysfunction.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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