Yunxia Bi,Mohammed Abdul Rahman,James David Lester
申请号：
US14344705
公开号：
US20150011525A1
申请日:
2012.09.13
申请国别(地区):
US
年份:
2015
代理人:
摘要：
A stable ternary solid dispersion composition with enhanced physical stability and/or bioavailability comprising: (a) about 1% wt. to about 50% wt. of one or more poorly soluble active pharmaceutical ingredient (API) which belongs to Biopharmaceutics Classification System (BCS) class II and/or IV (b) about 11% wt. to about 50% wt. of at least one water-soluble polymer and (c) about 20% wt. to about 99% wt. of crosslinked polyvinylpyrrolidone (crospovidone, a water-insoluble polymer). The solid dispersion is capable of inhibiting crystallization of API in solid state and/or aqueous gastrointestinal tract (GIT) medium. Also disclosed is a method of preparation of such solid dispersion composition by fusion or solvent or fusion-solvent method.
