An expandable medical device includes a plurality of elongated struts,forming a substantially cylindrical device which is expandable from a firstdiameter to a second diameter. A plurality of different beneficial agents maybe loaded into different openings within the struts for delivery to:thetissue.For treatment of conditions such as restenosis, different agents are loadedinto different openings in the device to address different biologicalprocessesinvolved in restenosis and are delivered at different release kinetics matchedto the biological process treated. The different agents may also be used toaddress different diseases from the same drug delivery device. In addition,anti-thrombotic agents may be affixed to at least a portion of the surfaces ofthe medical device for the prevention of sub-acute thrombosis. To ensurethat the different agents remain affixed to the device as well as to eachother, primer layers may be utilized.
