The present invention discloses a method of extracting arterial input function and its application for dynamic contrast enhanced magnetic resonance imaging (DCE-MRI), which includes: firstly injecting the contrast agent into a target tissue to obtain the continuous images obtaining the concentration-time curve of the contrast agent presented at each voxel based on the continuous images, and thus automatically estimating the purity for the tissue concentration curve of each voxel extracting the voxel having the maximum purity to be selected as the best artery position, and then extracting the tissue concentration curve as the arterial input function and, applying the arterial input function to a pharmacokinetics model to obtain the corresponding pharmacokinetics parameters. Thus, the present invention cannot only enhance the accuracy and reliability of derived quantitative indicators, but also enhance the efficiency of quantitative analysis.本發明係揭露一種萃取動脈輸入函數之方法及其於動態對比增強磁振造影(DCE-MRI)之應用,其係先注射顯影劑至目標組織中,根據取得的連續影像將顯影劑在每一體素所呈現的濃度時間曲線(組織濃度曲線),藉此自動估算每一體素的組織濃度曲線之純度;之後萃取出具有最大純度之體素選擇具有最大純度的體素視為最佳動脈的位置,再萃取該體素的組織濃度曲線作為動脈輸入函數。之後若將此動脈輸入函數應用於一藥物動力學模型中,即可獲得對應的藥物動力學參數。如此,本發明不但可增進推導出來的量化指標的準確性與可靠性,亦可提高量化分析時的效率。
