pharmaceutical composition containing hemoglobin-based oxygen carrier for cancer treatment and prevention of cancer relapse and use of hemoglobin-based oxygen carrier
KWOK, Sui, Yi,LAU, Sze, Hang,WAI, Norman Fung, Man,WONG, Bing, Lou
申请号：
BR112015007475
公开号：
BR112015007475A2
申请日:
2013.10.11
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
abstract "pharmaceutical composition containing hemoglobin oxygen carrier for cancer treatment and prevention of cancer relapse and use of hemoglobin oxygen carrier". The present invention relates to a pharmaceutical composition containing a hemoglobin-based oxygen carrier for treating cancer, preventing cancer tumor recurrence and metastasis. The composition may be used alone or in combination with at least one chemotherapeutic agent such as 5fu, bortezomib, doxorubicin, cisplatin, or any combination thereof. The hemoglobin-based oxygen carrier in the composition is capable of targeting a surface receptor expressed in cancer cells and facilitates absorption of both the hemoglobin-based oxygen carrier and the chemotherapeutic agent by cancer cells through a receptor-mediated mechanism. The hemoglobin-based oxygen carrier inhibits expression of hypoxia-responsive elements such as hif1α, vegf, et1, vhl, etc. The pharmaceutical composition of the present invention is also useful for inducing apoptosis or cell death of a type of self-renewing tumor-initiating cells called cancer stem cells which are in the hypoxic niche of the cancerous tumor. 1/1resumo “composição farmacêutica contendo carreador de oxigênio à base de hemoglobina para tratamento voltado para o câncer e prevenção de recidiva do câncer e utilização do carreador de oxigênio à base de hemoglobina”. a presente invenção se refere a uma composição farmacêutica contendo um carreador de oxigênio à base de hemoglobina para tratar o câncer, evitando a recidiva e metástase de tumor canceroso. a composição pode ser usada sozinha ou em combinação com pelo menos um agente quimioterapêutico tal como o 5fu, bortezomib, doxorrubicina, cisplatina, ou qualquer combinação dos mesmos. o carreador de oxigênio à base de hemoglobina na composição é capaz de atingir um receptor de superfície expresso em células cancerosas e facilitar a absorção tanto do carreador de oxigênio à base de hemoglobina quanto do agente quimioterapêuti
