An expandable surgical access device can include an elongate member comprising an expansion lumen between a proximal end and a distal end, and an expandable body operably attached to the distal end of the elongate member. The expandable body can be inserted to an internal location in a body in a collapsed configuration. When in a desired position, the expandable body can be expanded outward to an expanded configuration. In the expanded configuration, the expandable body can be adapted to protect adjacent anatomical structures and can have an internal diameter defining an operating lumen sufficient to allow passage of a cannula through the operating lumen. The expandable body may be further expanded inward to a constricting configuration whereby the expandable body can be adapted to constrict about and anchor the cannula in the operating lumen.
