The present invention relates to active compound combinations and compositions for reducing the damage of plants and plant parts as well as losses in harvested fruits or vegetables caused by insects nematodes or phytopathogens and which have fungicidal or nematicidal or insecticidal activity including any combination of the three activities in particular within a composition which comprises (A) Fluopyram (B) a sporeforming bacterium of the genera Bacillus selected from Bacillus firmus Bacillus cereus Bacillus pumilis Bacillus amyloliquefaciens Bacillus subtilis strain GB03 Bacillus subtilis strain QST713 and (C) at least one biological control agent in particular bacteria fungi or yeasts protozoa viruses entomopathogenic nematodes inoculants botanicals and products produced by microorganisms including proteins or secondary metabolites. Moreover the invention relates to a method for curatively or preventively controlling insects nematodes or phytopathogens on the plant plant parts harvested fruits or vegetables to the use of a combination according to the invention for the treatment of seed to a method for protecting a seed and not at least to the treated seed.