A method of plicating a stomach by accessing the exterior of a stomach of a patient and grasping tissue on a first and second location on a first side of the greater curvature of the stomach. Also forming a plication therebetween with a first staple. The method involves grasping tissue on a third and fourth location on a second side of the greater curvature of the stomach and forming a plication with a second staple. The first and second plications are near a location selected from the group consisting of a gastroesophageal junction, a pylorus, and an incisura angularis. The method further includes grasping tissue on a first and second side of a greater curvature of the stomach and forming a fold along a length of the greater curvature by attaching the first and second sides together along a first attachment line with a first plurality of staples.
