D'ANGELO, IGOR EDMONDO PAOLO,NG, GORDON YIU KON,DIXIT, SURJIT BHIMARAO,SANCHES, MARIO
申请号：
CA2878640
公开号：
CA2878640A1
申请日:
2013.07.12
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Provided herein are multifunctional heteromultimer proteins. In specific embodiments is a heteromultimer comprising: at least two polypeptide constructs, each polypeptide construct comprising at least one cargo polypeptide attached to a transporter polypeptide, said transporter polypeptides derived from a monomeric native protein such that said monomeric constructs associate to form the heteromultimer and said transporter polypeptides associate to form a quasi-native structure of the monomeric native protein or analog thereof. These therapeutically novel molecules encompass heteromultimers comprising constructs that function as scaffolds for the conjugation or fusion of therapeutic molecular entities (cargo polypeptides) resulting in the creation of bispecific or multivalent molecular species. Provided herein is a method for creation of bispecific or multivalent molecular species.
