Disclosed herein are compositions that comprise copolymer-1 and an anesthetic agent. Also provided are methods that include the administration of a composition comprising copolymer-1 and an anesthetic agent. Such methods are useful for the treatment of multiple sclerosis for reducing the occurrence and/or severity of the side effects associated with a therapeutic regimen comprising administration of copolymer-1 and for increasing patient compliance with a therapeutic regimen comprising administration of copolymer-1.
