Keith A. Bowman,Noah Gardner,Travis Jeannotte,Chandra Vargeese
申请号：
US16425990
公开号：
US20190321295A1
申请日:
2019.05.30
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Encapsulated nucleic acid nanoparticles of uniformly small particle size are produced by intersecting one or more nucleic acid streams with one or more lipid streams. The encapsulated nucleic acid nanoparticles include a nucleic acid encapsulated within a lipid nanoparticle host. Uniformly small particle sizes are obtained by intersecting an aqueous nucleic acid stream and a stream of lipids in organic solvent at high linear velocities and with total organic solvent concentrations less than 33%.
