Method for site-specific preparation of polyethylene glycol-GRF conjugate

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专利权人:

メルク・セローノ・ソシエテ・アノニム

发明人:

ヴェロネーゼ，フランチェスコ・マリア,カリチェーティ，パオロ,スキアヴォン，オッドネ,ヴェロネーゼ,フランチェスコ・マリア,カリチェーティ,パオロ,スキアヴォン,オッドネ

申请号：

JP2009251100

公开号：

JP5431874B2

申请日:

2009.10.30

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

A method is described for the site-specific preparation of hGRF-PEG conjugates containing one or more PEG units (per mole of hGRF) covalently bound to Lys<；12>； and/or Lys<；21>； and/or N<； alpha >；, characterized in that the conjugation reaction between the hGRF peptide and activated PEG is carried out in solution and the desired hGRF-PEG conjugate can be purified by chromatography. The conjugates prepared by this method, as well as their use in the treatment and/or diagnosis of growth hormone deficiency, are also an object of the present invention.

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