CHEN, GUOHUA,DIONNE, KEITH E.,HOM, LAWTON,LAUTENBACH, SCOTT D.
申请号：
ES06017948
公开号：
ES2378675T3
申请日:
1998.07.24
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
Supply system for the controlled delivery of a beneficial agent comprising: an implantable capsule comprising an inner surface and an opening； a depot of beneficial agent inside the capsule for the supply of the beneficial agent at a predetermined delivery rate； a membrane obturator received at the opening of the capsule and providing a fluid permeable barrier between the interior and exterior of the capsule, the membrane obturator having a plurality of external projections to engage the interior surface of the capsule； wherein (a) the capsule has a plurality of grooves on its inner surface to receive the corresponding external projections of the membrane plug, and each external projection has a diameter of 1% less than 8% greater than the internal diameter of the groove of corresponding capsule； and / or (b) the diameter of the membrane obturator core between the external projections is between 0.5 and 15% less than the inner diameter of the capsule； wherein the diameter of the outer shoulder and / or the diameter of the core of the membrane plug between the outer shoulders is preselected to reach the predetermined supply rate at which the beneficial agent is supplied from the tank.Sistema de suministro para el suministro controlado de un agente beneficioso que comprende: una cápsula implantable que comprende una superficie interior y una abertura； un depósito de agente beneficioso en el interior de la cápsula para el suministro del agente beneficioso a una velocidad de suministro predeterminada； un obturador de membrana recibido en la abertura de la cápsula y que proporciona una barrera permeable al fluido entre el interior y el exterior de la cápsula, presentando el obturador de membrana una pluralidad de resaltes externos para acoplarse a la superficie interior de la cápsula； en el que (a) la cápsula presenta una pluralidad de estrías en su superficie interior para recibir los resaltes externos correspondientes del obturador de membrana, y cada resalte externo p
