Robert DEVITA,Andrew STEWART,Avner SCHLESSINGER,Kunal KUMAR,Peter MAN-UN UNG,Hui WANG,Hailing LI
申请号：
US16765542
公开号：
US20200306257A1
申请日:
2018.11.20
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention is directed to kinase inhibitor compounds having the following structure: or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof, where R1, R2, X, n, R3, Y, Z, R4, R5, R6, and = are as defined herein. The present invention also relates to compositions containing the kinase inhibitor compounds, methods of inhibiting activity of a kinase in a cell, methods of increasing cell proliferation in a population of pancreatic beta cells, methods of treating a subject for a condition associated with insufficient insulin secretion, and methods of treating a subject for a neurological disorder.
