Ivan M. Borrello,Susan Lee,Kimberly A. Noonan,Drew M. Pardoll
申请号：
US15742684
公开号：
US20180200367A1
申请日:
2016.07.08
申请国别(地区):
US
年份:
2018
代理人:
摘要：
In some embodiments, marrow-infiltrating lymphocytes (“MILs”) comprising a chimeric antigen receptor (“CAR”) are provided. In some aspects, the embodiments relate to a method for making a recombinant MIL, comprising obtaining bone marrow comprising MILs； and transfecting, transforming, or transducing the MILs with a nucleic acid encoding a chimeric antigen receptor. In some aspects, the embodiments relate to a method for treating a condition in a subject, comprising administering to the subject a MIL comprising a CAR.
