The invention discloses a kind of Chinese medicine compositions, preparation method and its preparation for treating malignant tumour.The bulk pharmaceutical chemicals of the Chinese medicine composition form:Common Camptotheca Fruit, brucea fruit oil, Chinese blister beetle (system), radix euphorbiae lantu (system), the rhizoma bolbostemmae, Glabrous Sarcandra Herb, selfheal, curcuma zedoary, Radix Astragali, Radix Salviae Miltiorrhizae, Poria cocos, Radix Notoginseng, Phellinus, dandelion, gynostemma pentaphylla, Radix Glycyrrhizae, tealeaves.The medicine can effectively inhibit the existence of cancer cell when for treating malignancy disease, adjust because malignant tumour causes internal acid-base imbalance and redox state unbalance, maintain the state stability of vivo environment, promote normal cell metabolism, with the advantages of good effect, toxic side effect is small.