THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC)
发明人:
JEONG, HYE GWANG,정혜광,KIM, HYUNG GYUN,김형균,NA, MIN KYUN,나민균
申请号：
KR1020130026035
公开号：
KR1013226610000B1
申请日:
2013.03.12
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A composition for preventing or treating breast cancer and ovarian cancer, comprising mollugin is provided to have excellent effect of killing cancer cells. CONSTITUTION: A composition for preventing or treating breast cancer and ovarian cancer comprises mollugin of chemical formula 1. The breast cancer or ovarian cancer is a cancer that the gene of human epidermal growth factor receptor 2 (HER2) is overexpressed. The composition suppresses HER2/Akt/sterol regulatory element binding proteins (SREBPs). A pharmaceutical composition for preventing or treating breast cancer and ovarian cancer comprises the mollugin and a pharmaceutical exipient. The mollugin in the pharmaceutical composition is comprised in a ratio of 0.001-99.9 wt%.본 발명은 몰루긴(mollugin)을 함유하는 유방암 또는 난소암의 예방 또는 치료용 조성물에 관한 것으로서, 상기 조성물은 HER2가 과발현된 유방암 세포와 난소암 세포에서 HER2(human epidermal growth factor receptor 2)/Akt/SREBPs(sterol regulatory element binding proteins)를 통해 FAS(fatty acid synthase)의 발현을 저해하고 유방암 세포와 난소암 세포의 세포 증식 억제 및 아폽토시스를 유도함으로써, 상기 암세포들을 사멸하는 효과가 우수하여, 유방암 또는 난소암의 치료용 조성물로 유용하게 사용될 수 있다.
