Arshad M. Siddiqui,Stephane Ciblat,Martin Dery,Lea Constantineau-Forget,Chantal Grand-Maitre,Nicolas Bruneau-Latour,Gerald W. Shipps,Alan B. Cooper,Vibha Oza,Matthew W. Kostura,Michael Luther,Jedd Lev
申请号：
US16465136
公开号：
US20190345152A1
申请日:
2017.11.29
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Disclosed are compounds useful, for example, in methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formulae (Ia), (Ib), (Ic), (Id) and (Ie), in which R1, L1, L2, Q, L3, R3, L4, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.
