An analyte monitoring device operable to draw a fluid sample from a subject. The device comprises a first plurality of microneedles, a plurality of monitoring microchannels, wherein each of the first plurality of microneedles is at least intermittently in fluid communication with a corresponding monitoring microchannel, and wherein each monitoring microchannel is associated with a reagent, at least one actuator operable to extend each microneedle to draw the fluid sample from the, subject, and a controller operable to initiate analyte testing of the fluid sample.