The Broad Institute, Inc.;Massachusetts Institute of Technology
发明人:
Edward Holson,Florence Fevrier Wagner,Michel Weiwer,Edward Scolnick,Michelle Palmer,Luka Dordevic,Michael C. Lewis,Jennifer Q. Pan,Yan-Ling Zhang,Qihong Xu
申请号：
US15537741
公开号：
US20180155283A1
申请日:
2015.12.18
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to novel dopamine D2 receptor ligands. The invention further relates to functionally-biased dopamine D2 receptor ligands and the use of these compounds for treating or preventing central nervous system and systemic disorders associated with dysregulation of dopammode inergic activity. The present invention relates to novel compounds that modulate dopamine D2 receptors. In particular, compounds of the present invention show functional selectivity at the dopamine D2 receptors and exhibit selectivity downstream of the D2 receptors, on the 0-arrestin pathway and/or on the cAMP pathway.
