HANNEY, BARBARA,KIM, YUNTAE,KROUT, MICHAEL R.,MEISSNER, ROBERT S.,MITCHELL, HELEN J.,MUSSELMAN, JEFFREY,PERKINS, JAMES J.,WANG, JIABING
申请号：
CA2569124
公开号：
CA2569124C
申请日:
2005.06.03
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Compounds of structural formula I are modulators of the androgen receptor (AR)in a tissue selective manner. Thesecompounds are useful in the enhancement of weakened muscle tone and thetreatment of conditions caused by androgen deficiencyor which can be ameliorated by androgen administration, includingosteoporosis, osteopenia, glucocorticoid-induced osteoporosis,periodontal disease bone fracture, bone damage following bone reconstructivesurgery, sarcopenia, frailty, aging skin, malehypogonadism, postmenopausal symptoms in women, atherosclerosis,hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia andother hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia(BPH), abdominal adiposity, metabolic syndrome, type II diabetes, cancercachexia, Alzhheiner's disease, muscular dystrophies,cognitive decline, sexual dysfunction, sleep apnea, depression, prematureovarian failure, and autoimmune disease, alone or incombination with other active agents.
