ROSSOMANDO, ANTHONY,SILVIAN, LAURA,PEPINSKY, R. BLAKE
申请号：
CA2577755
公开号：
CA2577755C
申请日:
2005.08.18
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Variant Neublastin polypeptides having substitutions at selected amino acidresidues are disclosed. Substitution at one or more selected amino acidresidues decreases heparin binding and increases serum exposure of variantNeublastin polypeptides. Also disclosed are methods of using variantNeublastin polypeptides to treat disorders and activate the RET receptor in amammal.
