A system includes a probe configured to transmit ultrasound signals directed to a target blood vessel and receive echo information associated with the transmitted ultrasound signals. The system also includes at least one processing device configured to process the received echo information and generating a three-dimensional ultrasound image of the target blood vessel； obtain a three-dimensional vascular model corresponding to the target blood vessel； identify a best-fit of the three-dimensional vascular model onto the three-dimensional target image； store the best fit of the three-dimensional vascular model as a segmentation result； and calculate, based on the segmentation result, measurements for the target blood vessel.
