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СОСТАВЫ, СОДЕРЖАЩИЕ МОЛЕКУЛЫ ФАКТОРА, ВЫСВОБОЖДАЮЩЕГО ГОРМОН РОСТА (GRF), С УЛУЧШЕННОЙ СТАБИЛЬНОСТЬЮ
专利权人:
ТЕРАТЕКНОЛОДЖИЗ; ИНК. (CA)
发明人:
ШИНДЖЕЛ Кирилл (CA),ФЛЕРИ Даниель (CA)
申请号:
RU2015141675
公开号:
RU2015141675A
申请日:
2014.02.26
申请国别(地区):
RU
年份:
2017
代理人:
摘要:
Stabilized solid and liquid pharmaceutical formulations comprising a GRF molecule as active ingredient, such as GRF analogs including those comprising an N-terminal-attached hydrophobic moiety, such as [trans-3-hexenoyl]hGHRH (1-44) amide, are disclosed. The formulation comprises a GRF molecule or a pharmaceutically acceptable salt thereof and a &bgr-cyclodextrin which is not conjugated to the GRF molecule or salt thereof. Also disclosed is the use of the formulation for the treatment of various conditions, methods of preparing the formulation, as well as kits containing it. Methods of stabilizing (e.g., with respect to chemical stability) such GRF molecules, as well as methods of inhibiting their deamidation at Asn8, are also disclosed.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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