In some aspects the invention provides methods of treating a subject in need of treatment for a chronic complement mediated disorder. In some aspects the invention provides methods of treating a subject in need of treatment for a Thl7 associated disorder. In some aspects the invention provides methods of treating a subject in need of treatment for a chronic respiratory system disorder. In some aspects the invention provides methods of administering a complement inhibitor to a subject. In some embodiments a method of treating a subject comprises administering multiple doses of a complement inhibitor to the subject according to a dosing schedule that leverages the prolonged effect of complement inhibition in chronic respiratory disorders. In some embodiments a subject has chronic obstructive pulmonary disease. In some embodiments a subject has asthma.
