Albert Duranton,Christine Collin-Djangone,Francis Pruche,Jean-Thierry Simonnet
申请号：
US12007387
公开号：
US09012418B2
申请日:
2008.01.09
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Expression of a messenger RNA which encodes a protein which is expressed by differentiated cells, notably the cells of the skin or appendages thereof, is inhibited by topically administering to said differentiated cells a thus effective amount of at least one double-stranded RNA oligonucleotide, formulated into a topically applicable, physiologically acceptable medium therefor such regime or regimen is useful for treating a variety of afflictions or conditions, e.g., combating the signs of skin aging, stimulating hair growth or retarding loss thereof, inhibiting cellular proliferation and/or differentiation, etc.
