HEKSAHIDROPIROL[3,4-C]PIROLO DARINIAI IR SUSIJĘ JUNGINAI KAIP AUTOTAKSINO (ATX) INHIBITORIAI IR KAIP LIZOFOSFATIDINĖS RŪGŠTIES (LPA) GAMYBOS INHIBITORIAI, SKIRTI GYDYTI PVZ., INKSTŲ LIGAS

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专利权人:

F. Hoffmann-La Roche AG

发明人:

HERT, Jérôme,HUNZIKER, Daniel,MATTEI, Patrizio,MAUSER, Harald,TANG, Guozhi,WANG, Lisha

申请号：

LT13766056

公开号：

LT2900669T

申请日:

2013.09.23

申请国别(地区):

LT

年份:

2019

代理人:

摘要：

The invention provides hexahydropyrrolo[3,4-c]pyrrole derivatives and related compounds of formula (I) as autotaxin (ATX) inhibitors and as inhibitors of the lysophosphatidic acid (LPA) production for treating e.g. renal conditions, liver conditions, inflammatory conditions, conditions of the nervous system, conditions of the respiratory system, vascular and cardiovascular conditions, fibrotic diseases, cancer, ocular conditions, metabolic conditions, cholestatic and other forms of chronic pruritus and acute and chronic organ transplant rejection.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/