KNUST HENNER,NETTEKOVEN MATTHIAS,RATNI HASANE,RIEMER CLAUS,VIFIAN WALTER
申请号：
IN5377/CHENP/2011
公开号：
IN2011CN05377A
申请日:
2011.07.25
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
The present invention relates to a compounds of formula I wherein Ar1 is aryl or a six membered heteroaryl Ar2 is aryl or a six membered heteroaryl R1 is hydrogen, halogen, lower alkyl, lower alkoxy or lower alkyl substituted by halogen R2 is hydrogen, halogen, lower alkyl, lower alkyl substituted by halogen or cyano R3 is hydrogen or lower alkyl R4 is hydrogen, lower alkyl, phenyl, optionally substituted by halogen, or is a five membered heteroaryl, optionally substituted by lower alkyl, or is aryl optionally substituted by halogen is a six memberedjieterocyclic group, wherein X is -N(S02CH3) R6 is hydrogen Y is -N(R7")-R7 is a 6-membered heteroaryl group, optionally substituted by cyano or C(0)-cycloalkyl, wherein the cycloalkyl group is optionally substituted by lower alkyl2 n is 1 m is 1 o is 1 p is 1 s is O t is 1 u is 1 or to a pharmaceutically active salt, a racemic mixture, an enantiomer, an optical isomer or a tautomeric form thereof. It has been found that the present compounds are high potential NK-3 receptor antagonists for the treatment of depression, pain, psychosis, Parkinson"s disease, schizophrenia, anxiety and attention deficit hyperactivity disorder (ADHD).
