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CANNABINOIDS IN COMBINATION WITH NON-CANNABINOID CHEMOTHERAPEUTIC AGENTS (eg, SMRE or ALKYLating AGENTS)
专利权人:
ДжиДаблЮ ФАРМА ЛИМИТЕД (GB);ОЦУКА ФАРМАСЬЮТИКАЛ КО. ЛИМИТЕД (JP)
发明人:
ВЕЛАСКО ДИЕС Гильермо (ES),ГУСМАН ПАСТОР Мануэль (ES),ЛОРЕНТЕ Мар (ES),ТОРРЕС София (ES)
申请号:
RU2010154672/15
公开号:
RU2010154672A
申请日:
2009.06.04
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. The combination of cannabinoids tetrahydrocannabinol (THC) and cannabidiol (CBD) in a ratio of 5: 1 to 1: 5 and a non-cannabinoid chemotherapeutic agent for use in the treatment of brain tumors. ! 2. The combination of cannabinoids tetrahydrocannabinol (THC) and cannabidiol (CBD) according to claim 1, where the treatment of a brain tumor is to reduce cell viability, inhibit cell growth or reduce tumor volume. ! 3. The combination of cannabinoids tetrahydrocannabinol (THC) and cannabidiol (CBD) according to claim 1, where the ratio of THC and CBD is from 2: 1 to 1: 2. ! 4. The combination of cannabinoids tetrahydrocannabinol (THC) and cannabidiol (CBD) according to claim 1, where the ratio of THC and CBD is approximately 1: 1. ! 5. The combination of cannabinoids tetrahydrocannabinol (THC) and cannabidiol (CBD) according to claim 1, where the total number of cannabinoids is in the range between 5 and 100 mg. ! 6. The combination of cannabinoids tetrahydrocannabinol (THC) and cannabidiol (CBD) according to claim 1, where the non-cannabinoid chemotherapeutic agent is a selective modulator of the estrogen receptor. ! 7. The combination of cannabinoids tetrahydrocannabinol (THC) and cannabidiol (CBD) according to claim 6, where the selective modulator of the estrogen receptor is selected from the group consisting of: afimoxifene (4-hydroxytamoxifen); arzoxifene; bazedoxifene; clomiphene; lazofoxifene; oromeloxyphene; raloxifene; tamoxifen and toremifene. ! 8. The combination of cannabinoids tetrahydrocannabinol (THC) and cannabidiol (CBD) according to claim 7, where the selective modulator of the estrogen receptor is one of: raloxifene; tamoxifen and toremifene. ! 9. The combination of cannabinoids tetrahydrocannabinol (THC) and cannabidiol (CBD) according to claim 1,1. Комбинация каннабиноидов тетрагидроканнабинола (ТГК) и каннабидиола (КБД) в соотношении от 5:1 до 1:5 и неканнабиноидного химиотерапевтического агента для применения в лечении опухоли мозга. ! 2. Комб
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