The Tuo Xi Suan Which and its polymorphic, its Men System Prepare method and purposes of Ben and Er Dan Miscellaneous derivative农业专利-农业学术服务平台

专利权人:: JIANGSU HENGRUI MEDICINE CO.; LTD.;江蘇恒瑞醫藥股份有限公司;JIANGSU HENGRUI MEDICINE CO., LTD.;江苏恒瑞医药股份有限公司

发明人:: SUN, Piaoyang,孙飘扬,孫飄揚,WU, Guaili,武乖利,GAO, Xiaohui,高晓辉,高曉輝,ZHANG, Quanliang,张全良,張全良,CHEN, Yongjiang,陈永江,陳永江

摘要：: The bright Tuo Xi Suan Which for being related to Ben and Er Dan Miscellaneous derivative of this Hair and its polymorphic, its Men System Prepare method and purposes , Te Do be 3- [(4s) -8- bromo- 1- methyl -6- (2- pyridyl group) -4H- imidazoles [1,2-a][1,4] Ben and Er Dan Miscellaneous -4- base] methyl propionate (I) Tuo Xi Suan Which polymorphic Ji Qi System Prepare method and purposes. Bright obtained formula (I) the compound Tuo Xi Suan Which Knot of this Hair is brilliant, and molten Elixirs Disabled stays low, and Steady is qualitative good, can preferably Yong Yu Pro control Treatment.本發明涉及苯并二氮雜䓬衍生物的托西酸鹽及其多晶型、它們的製備方法和用途，特別是3-[(4s)-8-溴-1-甲基-6-(2-吡啶基)-4H-咪唑[1,2-a][1,4]苯并二氮雜䓬-4-基]丙酸甲酯(I)的托西酸鹽多晶型及其製備方法和用途。本發明所得到的式(I)化合物托西酸鹽的結晶，溶劑殘留低，穩定性良好，可更好地用於臨床治療。