A system for actuating a boom assembly of an agricultural sprayer, the system having a frame, a boom assembly supported relative to the frame, and a linkage assembly configured to couple the boom assembly to the frame. The linkage assembly includes a support arm pivotably coupled between the frame and the boom assembly, a lift actuator pivotably coupled between the frame and the support arm and configured to raise and lower the boom assembly in a vertical direction, and a tilt actuator pivotably coupled between the frame and the boom assembly and configured to adjust a tilt angle of the boom assembly relative to the vertical direction. The system further includes a controller configured to selectively actuate the tilt actuator to adjust the tilt angle of the boom assembly to an operational tilt angle.