您的位置: 首页 > 农业专利 > 详情页

pharmaceutical compositions comprising rifamixin and amino acids, method of preparation and use thereof
专利权人:
ALFA WASSERMANN S.P.A.
发明人:
DARIO BRAGA,FABRIZIA GREPIONI,GIUSEPPE CLAUDIO VISCOMI,LAURA CHELAZZI,MADDALENA KINDT
申请号:
BR112015000088
公开号:
BR112015000088A2
申请日:
2013.07.03
申请国别(地区):
BR
年份:
2017
代理人:
摘要:
Patent Summary: "Pharmaceutical compositions comprising rifamixin and amino acids, method of preparation and use thereof". It is the object of the present invention to provide rifamixin compositions comprising amino acids which increase the solubility of rifamixin in aqueous solutions. Rifamixin compositions comprising amino acids are useful in treating amino acid diseases and rifamixin are effective. The present invention relates to pharmaceutical compositions comprising rifamixin or one of the pharmaceutically acceptable salts thereof and one or more amino acids, wherein the amino acid to rifamixin molar ratio is between 1: 1 and 10: 1, preferably 1: 1 and 5: 1, together with pharmaceutically acceptable excipients. furthermore, the present invention relates to rifamixin crystals obtained by a process comprising: a) dissolving rifamixin and amino acid compositions, where amino acids and rifamixin are in molar ratio between 1: 1 and 10: 1, in solutions formed by ethanol / water, at a volumetric ratio of 1: 1 to 1:10 (v / v); b) evaporation of the solution obtained in (a) at temperatures between room temperature and 40 ° C, in a period of time between 1 and 10 days; where resulting crystals have the p21 monoclinic space group and cellular parameters in the ranges: a: 13.7 (1) -13.8 (1) å; b: 19.7 (1) -19.9 (1) å; c: 16.4 (6) -16.6 (6) δ; ß: 92.1 (1) -91.9 (1) degrees.resumo patente de invenção: "composições farmacêuticas compreendendo rifamixinaa e aminoácidos, método de preparação e uso das mesmas". constituem o objetivo da presente invenção composições de rifamixina compreendendo aminoácidos, que aumentam a solubilidade da rifamixina em soluções aquosas. composições de rifamixina compreendendo aminoácidos são úteis no tratamento de doenças nos aminoácidos e rifamixina são eficazes. a presente invenção refere-se a composições farmacêuticas compreendendo rifamixina ou um dos sais farmaceuticamente aceitáveis da mesma e um ou mais aminoácidos, em que a relação molar e
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
相关发明人
相关专利

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充